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Increased brain uptake and oxidation of acetate in heavy drinkers

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Published on Mar 8, 2013

Graeme Mason of Yale University discusses how heavy drinking influences metabolism and leads to alternate fuel use in the brain. Highlights:

• Brain acetate consumption is inducible by conditions that can occur with heavy alcohol use.

• Heavy drinking is associated with enhanced ability to import and oxidize acetate.

• Systemic acetate provides a potential metabolic reward for drinking, possibly specific to glia.

• Acetate oxidation provides a mechanism to generate adenosine, whose loss may contribute to withdrawal symptoms.

Article: http://www.jci.org/articles/view/65153

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Spanish: http://www.youtube.com/watch?v=ipLPyi...

Portugese: http://www.youtube.com/watch?v=IIGN6E...

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