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Published on Apr 28, 2014
We developed a new gene construct "CEST reporter" which after its incorporation in glioma cells resulted in the production of magnetic resonance imaging MRI visible proteins. These proteinexpressing tumor cells were transplanted into the brain of living mice and allowed to grow. A week after transplantation we imaged these live mice with MRI which enabled us to clearly see the tumor cells growing in the brain. We are now using our new MRI reporter gene technology with cell therapy where we track the survival growth and migration of transplanted stem cells.