 The Martini III coarse-grained model has been developed to enable accurate simulations of large biomolecular complexes at Milisekin time scales. It combines a variety of beads and sizes with a new mapping approach, allowing it to accurately represent larger biomolecules than previous versions. This model has the potential to revolutionise drug discovery and development pipelines by providing more detailed insights into the behaviour of large biomolecules. Areas for further development include automatic parameterisation protocols for different molecule types, improved back mapping procedures, and methods for sampling the full chemical space. The model has already shown promise in the areas of membrane proteins, cryptic pockets, and protein-protein interactions, and it also has the potential to provide valuable insight into the development of soft drug delivery systems. This article was authored by Lisbeth Aukchelby, Gilberto P Pereira, Alessio Bartocchi, and others.