 This new method allows researchers to create novel gem-difluorinated isosteres from one, three, dirocyclobutanols in a single operation. It involves an acid-catalyzed unmasking fluorination sequence followed by an IIIIIII cycle and a phenonium ion rearrangement to form a one, three, three trifluoride. Finally, ACSP3F bond activation event with hydrogen fluoride enables the formation of the difluorinated tetraline scaffold. This article was offered by Joel Hafliga, Louise Ruyet, Niko Stubka, and others.