 Catorolactomethamine is an effective anti-inflammatory and analgesic agent, but its use has been limited due to potential side effects from systemic exposure. This study developed a novel topical delivery system for Catorolactomethamine using a three dimensional mesh structure made of dihydroxyaluminum aminoacetate, DAAA, and sodium polyacrylate. The resulting cataplasm had a gel-like elasticity and enhanced skin permeability. It also demonstrated comparable anti-inflammatory and analgesic effects when administered orally versus the tablet formulation. Additionally, the cataplasm was shown to reduce the risk of adverse events while maintaining efficacy, making it a promising alternative for treating inflammation, including osteoarthritis. This article was authored by Zhiyuan Hou, Chongwen, Winhuzhou, and others.