 This study provides an overview of the global burden of hospital-acquired drug-resistant infections. The authors estimate that there are approximately 136 million cases of these infections each year, with the highest burden in China, Pakistan, and India. Middle-income countries bear the greatest burden of these infections, suggesting that more resources should be allocated to addressing them. This article was offered by Ruchita Balasubramanian, Thomas P. Van Bokoal, Yehuda Kamali, and others.