 The study identifies a cluster of GABAergic neurons in Drosophila larval brain, called SEZ localized descending GABAergic neurons, SDGs, that prevent presynaptic activity through GABA receptor and suppresses gait behavior by attenuating nisoseption. Glucose feeding to starved larvae causes sustained activation of SDGs through glucose sensing neurons and subsequent insulin signaling in SDGs, which leads to the suppression of noxious stimuli and the prioritization of feeding over escape behavior. This article was authored by Mami Nakamizo Dojo, Kinichi Ishii, Jiro Yoshino, and others.