 This study aims to assess the acceptance of e-mental health interventions among patients with diabetes and explore its underlying barriers and resources using a cross-sectional survey based on the unified theory of acceptance and use of technology, Ataut, in Germany. The results show that the acceptance of e-mental health interventions in patients with diabetes is moderate, and three Ataut predictors, performance expectancy, effort expectancy, and social influence, reached a notable amount of explained variants of 75% in the acceptance. Owing to the close link between acceptance and use, acceptance-facilitating interventions focusing on these three Ataut predictors should be fostered to establish effective e-mental health interventions in psychodiabatology. This article was authored by Mirjim Damero, Martin Teufel, Venja Mush, and others.