 The COVID-19 pandemic has negatively impacted Italian psoriatic patients treated with biologics during the lockdown period in March to May 2020. A telephone survey was conducted among 226 patients, revealing that 27.9% experienced worsening of their disease due to drug withdrawal, which correlated with increased anxiety, depression and stress levels as measured by HADS, PSS and BRS scores. No correlation was found between worsening of psoriasis and work activity. The study suggests that uncertainty about the safety of biologics and psychological factors can influence the clinical course of psoriasis during the pandemic. This article was authored by Federico Pirro, Giacomo Calderola, Andrea Ciracosi and others.