 This paper presents the case of a young girl who was diagnosed with a genetic mutation causing monogenic obesity. The mutation was identified as a variant in the MC4R gene, which is responsible for regulating hunger and satiety hormones. Despite being prescribed a variety of medications, including metformin and orlostat, she did not see any improvement in her condition. Eventually, she was treated with lyriglotide, a GLP-1RA, which resulted in a 19.2% reduction in body weight and BMI over the course of 32 weeks. Unfortunately, however, the patient's treatment was discontinued due to severe gastrointestinal side effects. This case highlights the importance of identifying the underlying causes of obesity in order to develop more effective and tolerable treatments. This article was authored by Amin Kandasan, Asana Kinchi, Liman Kais, and others.