 We report a case of occupational monkeypox virus infection from a needle-stick injury in a healthcare worker in South Korea and review similar reports in the literature during 2022. Post-exposure prophylactic treatment with a third-generation smallpox vaccine and antiviral agent Tecoviramat inhibited local virus spread and alleviated lesion pain. This article was authored by Yoon Sang Choi, Moon Bye Jong, Tae Young Kim, and others.