 The traditional medicine and diets of mankind have been used for centuries to prevent and treat chronic diseases such as cancer. Recent research indicates that chronic inflammation plays a key role in these diseases and two transcription factors NF-Kappa B and STAT 3 are implicated in regulating inflammation, cellular transformation, and tumor cell survival, proliferation, invasion, angiogenesis, and metastasis. Triterpine compounds derived from traditional medicine and diet have been shown to inhibit NF-Kappa B and STAT 3 activation pathways, suggesting they may be effective in preventing and treating cancer. This article was authored by Bharat B. Uggarwal, Bakyan Sun, Sadiya Prasad, and others.