 Kidney failure may in itself also be a cause for coagulation problems with increased bleeding from surgery. The uremie associated with kidney failure decreases platelet adhesion, aggregation and release. Bleeding time is prolonged and proportional to the extent of the clotting defect. Desmo preson may correct this bleeding time but if the bleeding time does not correct and bleeding is a risk or problematic, a platelet transfusion should be considered. Emer dialysis may be required to correct the uremie.