 Zinc oxide nanoparticles, ZNONPs, are widely used in various industrial products and have emerged as a promising potential in biomedicine due to their excellent biocompatibility, low toxicity, and potent ability to trigger excess reactive oxygen species production, release zinc ions, induce cell apoptosis, keep the structural integrity of insulin, and show excellent luminescent properties for bioimaging. This article was authored by Gene Huang, Jiang, Jiang Pi, and GSAI.