 Abstract acute pancreatis, AP, is a serious inflammation of the pancreas which can lead to death if not treated quickly. Reactive oxygen species, ROS, are known to play a major role in the development of AP, as well as its severity. A new semiconductor polymer nanoplattform, SPN, was developed which emits chemiluminescence, CL, signals when exposed to ROS. These CL signals were found to correlate strongly with the severity of AP, making it possible to diagnose AP more accurately and quickly than before. Furthermore, this technology could also be used to monitor the progress of treatment and determine the severity of AP. This article was authored by Yuhang Lee, Baolien, Yinghui Song, and others.