 Volume-regulated anion channels, VIACs, composed of LRC8A e-proteins, mediate the transport of CL and organic solutes out of cells. These channels are heteromas, consisting of LRC8A e-proteins, which form hexamers or heptamers. The LRC8C LRC8A Illinois 125, Chimera, however, is a heptamer, like Panexin channels, and has a larger diameter than Homomeric LRC8A and LRC8D channels. Additionally, this Chimera has a lipid density that occludes the channel pore, suggesting that lipids may be involved in channel gating and regulation. This article was authored by Hiroha Tokahoshi, Toshiki Yamada, Jared S. Denton, and others.