 Psychological stress can have a significant effect on the skin's immune system, leading to increased susceptibility to certain skin conditions such as atopic dermatitis and psoriasis. The HPA axis and sympathetic nervous system are two key components in this process, with cortisol and other hormones released during stress playing a major role in altering the skin's immune response. Additionally, psychological stress can lead to decreased recovery time for wounds, reduced antigen presentation by epidermal langer hand cells, and exacerbation of immune-mediated dermatological disorders. By understanding the relationship between the psychonervous immune axis and skin diseases, dermatologists and psychiatrists can work together to develop more effective treatments for these conditions. This article was authored by Jessica M. F. Hall, DeSanges Cruiser, Alan Podewilts, and others.