 Transferring plays an important role in regulating iron levels in the body. It can be either apotransferrin or holotransferrin, depending on whether it has enough iron attached to it. Apotransferrin is low in iron and stimulates the release of iron from cells, while holotransferrin is high in iron and suppresses the release of iron. Hepsidin is another factor involved in regulating iron levels, and it can also affect the interaction between transferrin and ferroportin, the protein responsible for transporting iron out of cells. When Hepsidin is present in higher concentrations than normal, it can cause the transferrin ferroportin complex to break apart, preventing the release of iron. This study provides new insight into the mechanisms behind the regulation of iron levels in the body. This article was authored by Stephanie L. Behringer, Kandaya Palsa, Vladimir S. Begelman, and others.