 The soluble carrier hormone binding protein, HBP, plays an important role in the growth of human and other animals. Accurate identification of HBP is an important prerequisite for understanding its biological functions and molecular mechanisms. Machine learning-based method was proposed to identify HBP, in which the samples were encoded by using the optimal tripeptide composition. This article was authored by Joe Xiantan, Shurhao Li, Zimei Zheng, and others.