 The study found that six categories of barriers and enablers exist when it comes to implementing clinical practice guidelines, CPGs, in primary care settings. These include political, social, and cultural factors, institutional environment and resources factors, guideline itself related factors, healthcare provider related factors, patient related factors, and behavioral regulation related factors. The most common barrier was sub-optimal healthcare networks and inter-professional communication pathways, while the most common enabler was presence of technical support. Policy-driven strategies should be developed to motivate different levels of implementation activities, including optimizing resource allocations, promoting integrated care models, establishing well-coordinated multidisciplinary networks, increasing technical support, encouraging PCPs and patient's engagement in guideline development, standardizing the reporting of guidelines, increasing education and training, and stimulating PCPs and patient's motivations. All these activities should be conducted with consideration of the social, cultural, and community contexts to ensure successful and sustainable CPGs implementation. This article was authored by Dao Wang, Lu, Jin Yu, Benjamin, Tan, and others. We are article.tv, links in the description below.