 Qytosan is a versatile natural biomaterial with many beneficial properties, including its biocompatibility, hydrophilicity, biodegradability, and broad antimicrobial activity against both gram, negative and gram-positive bacteria, as well as fungi. It also features reactive functional groups which allow for the formation of electrochemical interactions at the cellular and molecular level. These unique properties have made it a popular choice among materials scientists who are developing new Qytosan-based biomaterials for use in dentistry. Additionally, the incorporation of Qytosan into existing dental materials can improve their performance. This article was authored by Shereer Hussein, Khalid H. Al-Samadani, Sharik Najib, and others.