 Radiation therapy, RT, and hyperthermia, HT, are two important components of cancer treatment. While both modalities have been shown to be effective, the mechanisms behind their success remain unclear. However, recent studies suggest that RT plus HT may be beneficial for cancer patients due to its ability to induce apoptosis, increase oxygenation, and disrupt the cell cycle. Additionally, it appears to enhance the immune system's response, potentially making it more effective against cancer. Taken together, these findings suggest that RT plus HT could be used as a complementary treatment to conventional therapy, providing a promising alternative to current methods. This article was authored by Son Kwan, Su Min-young, and Sung Ho-bak.