 Switzerland is ranked between the top countries in research and innovation but it's a continuous challenge to be on the top and institutions like SIV play a key role. But when we prepare the big sharing down of federal money every four years in general, the scientific community plays an important role because if we feel that something is necessary, appreciated and used by the scientific community, then we support it. It's not the top-down process made by some technocrats in Bern but really we'll say the better condition for SIV to be continually supported by the federal money is that the scientific community in this field recognized and testified the relevance of SIV. Thank to SIV was Switzerland's first mover in this field, in the international field and what happens later with Elixir and development in Europe shows first that there was a good example what we made in Switzerland. At the same time it gives to Switzerland a leading role that reflects as well our leading position in the research itself. If you ask which are the main challenges for science in the next years, personalized health and big data will be mentioned by everyone and I think in both fields the experience and the possibilities of SIV are key and especially for personalized health we gave a key role to SIV for the next step that has to be done in Switzerland.