 This study found that short-term glucosamine and chondroitin sulfate supplementation in combination with manual therapy and resistance exercise training did not significantly improve pain, function, quality of life, range of motion, strength, fall risk, skeletal muscle mass, visceral fat area, body fat, intracellular water ratio, or segmental lean and fat mass in people with neosteorthritis. However, it did show a significant increase in segmental lean mass of the right leg at the second week and of the left leg at the fourth week. This article was authored by Mohamed Osama, Mohamed Naveed Babur, Furqan Ahmed Siddiqui, and others.