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Published on Jun 18, 2013
In a media event held this morning, two of the world's most acclaimed cancer researchers, Drs. Tak Mak of the Princess Margaret Cancer Centre, and Dennis Slamon of the University of California, Los Angeles, shared news of a major breakthrough in the decade-long pursuit to develop a new class of "sharpshooter" cancer drugs.
"Dr. Slamon and I are proud to stand shoulder-to-shoulder with our fellow scientists and the donors who believe in our vision and have generously helped to finance our critical work," said Dr. Tak Mak, Director of The Campbell Family Cancer Research Institute at the Princess Margaret Cancer Centre. "Today we are excited to announce that we have submitted an Investigational New Drug (IND) application to the Food and Drug Administration for a new drug we have developed based on our research of a target enzyme, PLK4, which plays a crucial role in the process of cell division, particularly in cancer cells. We have been able to progress this project from our initial scientific observations through the complex stages of drug discovery and development to the point where we will shortly be able to test a drug in patients. It is extremely rare for an academic group to have discovered and advanced a novel "first-in-class" drug candidate to this level, and it would not have been possible without the fundamental support provided by donors."