 Silver nanoparticles, AGNPs, have gained increasing attention in recent years due to their wide range of applications in the medical field. They are particularly useful for topical drug administration and wound healing because of their high surface area to volume ratio and ability to penetrate deep into tissues. AGNPs can be synthesized using both traditional chemical methods and more environmentally friendly green synthetic methods. Characterization of these particles is essential for understanding their properties and optimizing their performance. This review focuses on green synthesized AGNPs loaded in polyacrylamide hydrogels for wound healing applications. It discusses the challenges and future perspectives of utilizing these nanoparticles for wound healing, including the optimization of particle size and release kinetics. This article was authored by Fahad M. Aldakil, Marwa M. L. Syed, Dahlia Mohsen and others.