 curcumin has been shown to have beneficial effects on insulin resistance in human umbilical vein endothelial cells, Huvix. It does this by reducing the accumulation of misfolded proteins in the endoplasmic reticulum, IR, which leads to less oxidative stress and inflammation. This reduces the activation of the ubiquitin proteasome system, UPS, and autophagy, which are two processes involved in ER protein degradation. By reducing these processes, curcumin helps to restore normal protein folding in the ER, which improves insulin sensitivity and reduces insulin resistance. This article was authored by Mao Yi, Mao Yi, Hong Chiu, and others.