 This review provides an overview of the use of transition metals in catalyzing domino reactions of strained bicyclic alkenes. It covers both HOMO and hetero-bicyclic alkenes, as well as their potential applications in organic synthesis. The review also discusses the substrate scope, reaction conditions, and potential applications. Finally, it looks at the reactivity paradigm of these alkenes and suggests possible future developments. This article was authored by Austin Pounder, Eric Neufeld, Peter Meiler, and others.