 Protein interaction networks have become increasingly important for understanding the underlying mechanisms of human diseases. Researchers have used these networks to identify genes and proteins associated with diseases, study network properties, and classify disease genes. Despite this progress, several challenges remain, including the need to integrate high throughput functional genomic data from multiple levels and the development of more personalized, accurate, and rapid diagnostics. Overall, protein interaction networks offer a promising approach to uncovering the molecular basis of diseases and developing new treatments. This article was authored by Tuba Savamoglu and Kazem Yeltsin Arga.