 Our next two presentations are sort of a tandem act or dual act, so I'd like to introduce both of the speakers, set the stage a little bit before they get into their presentations. One of the major sequencing programs that NHGRI supports is the Clinical Sequencing Exploratory Research Consortium, or CESAR, is the term that you're going to hear for the rest of the afternoon. Gail Jarvik from the University of Washington has graciously accepted our invitation and made the transcontinental trip to come and present on behalf of the CESAR Consortium to the Council. Les Beesiker is an investigator in the NHGRI Intramural Research Program, and he and his collaborators for three, four years. How long is the Coen Seek? Oh, long time gone. Okay. He's working on a distinct project with separate funding streams, but there's a lot of scientific overlap and methodological approaches that are in common between these two research programs, and in fact, Les is part of the CESAR Consortium. So we thought it would be interesting to have a presentation to the Council about what's going on in the extramural world and the intramural world, at least the NHGRI intramural world, about implementing genomic sequencing in the clinical setting. So the way we're going to structure this is Gail's going to go first and give you the presentation for the extramural consortium. And then we're going to take maybe two minutes' worth of just clarification questions for her, things that she would want to refer to her slides. Then Les will present, and then I'm going to ask both of them to come to the podium and we'll have something of kind of a forum discussion for broader issues, all related, at least in some way, to implementing genomic sequencing in the clinical setting. So, Gail, want to lead us off?