 This study examines the individual, communication and social determinants associated with vaccines uptake for COVID-19 in the United States. The results indicate that 68% and 65% agreed to get the vaccine for themselves and people under their care, respectively. Risk perceptions, exposure to conservative news outlets, party identification, and confidence in scientists were significant factors affecting vaccine uptake. Non-Hispanic blacks and those with leased schooling were also less likely to receive the vaccine. The study highlights the need for strategic public health communications to address these factors and increase COVID-19 vaccine uptake. This article was offered by K. Vishwanath, Meshfin Bekaloo, Dritty Dhawan, and others.