 Informed consent was already a challenge before the Covid-19 pandemic, but it became even more difficult due to the pandemic's restrictions on physical interactions between patients and researchers. To address these challenges, many CTSA institutions implemented new methods such as telephone calls, video conferencing, and online forms to obtain informed consent from participants. These changes allowed researchers to continue their work while still ensuring patient safety and protecting their rights. Additionally, these institutions learned valuable lessons about informed consent and are now better prepared to handle similar situations in the future.