 Hydrogels are three-dimensional networks composed of polymers that can absorb large quantities of water or biological fluids. These materials can incorporate active compounds and release them in a controlled manner. Additionally, hydrogels can respond to external stimuli such as temperature, pH, ionic strength, electrical or magnetic stimuli, specific molecules, etc., making them ideal candidates for a wide range of applications. In recent years, alternative methods for developing hydrogels have been proposed in the literature, while some hydrogels are toxic and should not be used in biomedical applications. However, nature provides a wealth of inspiration for the development of novel materials such as biomolecules like polysaccharides, proteins and polypeptides. These compounds possess a variety of physical and chemical properties which make them suitable for use in biomaterials such as biocompatibility, antimicrobial properties, biodegradability and non-toxicity. As a result, these compounds can generate microenvironments similar to those found in the human body making them ideal for applications such as drug delivery, tissue engineering and regenerative medicine. This article was authored by Alexandra Lapu, Wisa Madalina Grattonero, Basile Robert Grattonero and others. We are article.tv, links in the description below.