 This study uses site-space software to analyze 7385 bibliographic records from Web of Science to explore the intellectual landscape of monoclonal antibody, MAB, research, including thematic trends, landmark articles, and emerging trends. The analysis identifies four perspectives for examining MAB evolution, cited references, authors, institutions, and journals. The study reveals new directions for exploring MABs, interactions between MAB technologies and diseases, and evolving global collaboration among institutions. This article was authored by Yun Fenglai, Rui Bingwang, Xin Chen, and others.