 The results of this study suggest that SARS-CoV-2 vaccines are safe and effective in reducing the risk of infection, hospitalizations, intensive care unit admissions, and death caused by SARS-CoV-2. Furthermore, the vaccines are highly effective against the alpha, beta, gamma, and delta variants of SARS-CoV-2. This article was authored by Chao Liu, Chen Yuanqin, Minit Liu, and others.