 This paper presents a novel periodic cellular structure made of re-entrant hexagon-shaped honeycombs and Miura origami geometry, which was manufactured using selective laser melting, SLM, and tested for its compression deformation and energy absorption characteristics under quasi-static load in three directions. The results show that this structure has balanced mechanical properties with the z-direction being the best bearing direction, and exhibits a three-dimensional Poisson's ratio effect during compression. A numerical investigation using ANS-YS-LSDYNA was conducted to provide an accurate simulation method, and predictive formulas for critical energy absorption indexes were derived based on theoretical analysis and validated with experimental results. This article was authored by Chishuin Li, Zudong Xi, and Feng Fan.