 So first of all, I would like to extend my thank you to the foundation of behalf of Professor Terry Jones and myself To support our research into brain tumors. So our goal is very simple. All we want to achieve is to extend survival of the glioblastoma patient and glioblastoma is a very deadly cancer and people diagnosed with glioblastoma survive approximately one year and Brain cancer kills one Australian every eight hours. So it is also a very complex disease. So the research we don't exactly understand What is causing the formation of brain tumors? But what do we know today after decades of research? There is one protein in brain tumors that drive proliferation of these cancer cells and this protein called EGFR or Epidermal Growth Factor Receptor, which I call when I explain it to my student What it is? I say it's the bad guy that gives all the signals to the cells to proliferate which drives them Grub off the tumor. So what do we know that we have to stop this bad guy and Very simplistically all you need is a drug that will stop the function of this protein And this is true We have drugs in the clinic that will stop the functionic of EGFR and they are effective in treating lung cancer or colorectal cancer Unfortunately, these drugs they keep failing in clinical trials And now we know that the reason why they keep failing is that it's not enough only to stop this bad guy We also have to remove this receptor from the cell surface So me and Terry we came to this idea of trying a new drug combinations where we combine two drugs One drug will stop the functioning of EGFR and the other drug will remove this Protein from the cell surface and in the preliminary work that led to this Proposal that we put down to Brown Foundation We found out that this drug combination was extremely toxic to glioblastoma cells So we were very effectively killing the cancer cells But not the healthy cells of the brain the microglia, the astrocytes, the oligodendrocytes Which means that we might have a new drug combinations that will stop the brain tumors from growing So what we will do now with the very general sketch of the Brown Foundation is we will try this new drug combinations in primary cells from glioblastoma patients because glioblastoma is a very heterogeneous disease So we have the panel of cell lines and we want to find out which patients will respond best to this treatment We don't want to give it to the patients which might not respond to this therapy And then we will expand this research into animal models With this set of data we're hoping we will be ready to launch preclinical and maybe hopefully clinical trials that will Deliver the best the better therapy because what we have currently is very poor And as I said the glioblastoma people survive one year So any difference that we can make is great and Brown Foundation will enable this So thank you again for this very generous gift