 The Brazilian COVID-19 vaccination plan faces challenges such as a large territory, difficulty in delivering vaccines to remote areas, choice of vaccine based on storage and transport conditions, inclusion of indigenous individuals and healthcare workers, anti-vaccine movement, politicization of the vaccine, lack of correlation between markers and number of vaccines, and strong correlation between vaccines and COVID-19 cases, deaths, GDP, and population density. A total of 83.28 million doses were distributed in Brazil, with CoronaVac, AZD-1222, and BNT-162B being the most commonly used vaccines. The federal government needs to address these challenges to maximize immunization against COVID-19 in Brazil. This article was authored by Mateus Negri Bosteiro, Camila Vantini Capasso Palomín and Fernando Augusto Lima Marcin.