 This paper provides a comprehensive guide for biostatisticians who are involved in the review of research protocols. It outlines the elements of a research protocol that need to be considered when conducting a biostatistical review, and provides specific guidance on how each element should be evaluated. This guide will help biostatisticians navigate review boards and panels more effectively, ensuring that resources are not wasted on poorly planned studies. This article was authored by J. D. D. Silino, Kathy Spinoe, Walter T. Ambrosius and others.