 Quiescent cancer cells, QCCs, can survive chemotherapy and radiotherapy by residing in G0 phase, but may reproliferate and result in cancer progression if not targeted with specific agents. Understanding the mechanisms of QCC survival and activation is crucial for developing effective therapeutic modalities to prevent cancer progression and recurrence. This article was authored by one N.H.Barnignable, Jikir 11, Mengfeng Liu, and others.