 The awesome thing is there are so many drugs out there now approved for other cancers and drugs in development. So we just need to get our act together in terms of again sequencing what is the makeup of the tumor, what makes the tumor tick, what drug or combination of drugs could help a particular patient and then design a focused study because if you find that perfect combination you don't need to do a hundred patient study. You may get an answer in 10 patients. And so I think the more understanding of the science, the drivers of glioblastoma, the better drugs that we make, the more opportunities to accelerate the cures for this disease. And I am really excited I think for the next five years or so that I think we're going to see a lot more progress happen faster than ever before.