 Polymorphism is a common phenomenon among single and multi-component molecular crystals that can have a significant impact on the contemporary drug development process. In this study, two new polymorphic forms of the drug carbamazepine, CBZ, were synthesized and characterized. One form was a co-crystal with methylparaben, MEPRB, while the other was a channel-like co-crystal with co-formers of similar size and shape. Both forms were shown to be thermodynamically more stable than the original CBZ compound. Additionally, the dissolution performance of both polymorphs was improved over the original CBZ compound. Based on these findings, it appears that the newly discovered form II of the CBZ plus MEPRB, 1 colon 1, co-crystal may be a more suitable and reliable solid form for future pharmaceutical development. This article was authored by Artem Osurov, Ksenia V. Drauzd, Anna G. Ramazanova, and others.