 This study assesses factors associated with COVID-19 vaccine hesitancy in Portugal using data from a community-based survey, COVID-19 barometer, social opinion, conducted from September 2020 to January 2021. The study found that 56% of respondents would wait and 9% would refuse to take the vaccine. Several factors were associated with both refusal and delay, including being younger, loss of income during the pandemic, no intention of taking the flu vaccine, low confidence in the COVID-19 vaccine and health service response during the pandemic, worse perception of government measures, inconsistent and contradictory information provided, and answering the questionnaire before the release of safety and efficacy information about the vaccine. The study highlights the importance of building trust and improving communication to increase acceptance and uptake of the COVID-19 vaccine. This article was authored by Patricia Soares, Joao Victor-Rosha, Marta Moniz, and others. We are article.tv, links in the description below.