 This study proposes a novel approach to treating cancer by combining photodynamic therapy, PDT, magnetic hyperthermia, and immunotherapy. Nanoparticles called Janus nanobullets were developed which contain both photosensitive molecules and magnetic materials. These particles can be targeted to cancer cells and then activated using light or heat, depending on the type of nanoparticle used. Once activated, these particles cause cancer cells to die while leaving healthy cells unharmed. Additionally, the particles can also be heated using magnetic fields, further increasing the effectiveness of the treatment. Finally, this treatment was tested in mice with breast cancer and found to be effective at killing cancer cells and reducing the size of tumors. This article was authored by Zhang Wang, Fan Zhang, Dan Xiaoh, and others.