 This study examined the differences in breast cancer-specific survival rates among different subtypes of breast cancer, as well as the effectiveness of a surrogate classification system based on ER, PR, and her 2-status and tumor grade. The results showed that the luminal B her 2, subtype had a higher risk of mortality than the luminal B, her 2-plus subtype in all stages of disease. Additionally, there was no difference in risk of mortality between the ER-plus, PR-plus her 2, and ER-plus, PR-plus her 2-plus subtypes in stage 3. However, with the exception of stage 3, the ER-negative subtypes all had an increased risk of mortality when compared with the ER-positive subtypes. Furthermore, the surrogate classification provided clear separation in survival and adjusted mortality, but it also underestimated the wide variability within the subtypes that make up the classification. This article was offered by Carol A. Parise and Vincent Caggiano. We are article.tv, links in the description below.