 Antifungal drug resistance is a growing problem in many fungi, including candida and aspergillus species. Genetic mutations in drug-resistant gene expression have been identified as the primary causes of resistance. Recent studies have shown that environmental sources of resistance may be responsible for some cases of aspergillus fumigatus resistance, while multi-drug resistance, MDR, has been observed in certain candida species. These findings highlight the need for continued research into the development of new antifungals and strategies to prevent or manage antifungal resistance. This article was authored by Dominique E. Sanglert.