 Cellulose-based biomaterials are a promising platform for tissue engineering due to their unique properties such as tunability, biocompatibility, and low-cost. These materials offer many advantages over traditional synthetic materials, including the ability to mimic natural extracellular matrix, ECM, components and promote cellular adhesion. Furthermore, they can be used to create complex three-dimensional structures which can be used to control cell behavior and direct tissue growth. Nanostructural features of cellulose-based biomaterials also play an important role in their mechanical properties, allowing them to be used in a variety of applications ranging from fundamental science to biomedical engineering. This article was authored by Ryan Jay Hickey, Andrew E. Pelling, Andrew E. Pelling, and others.