 TRPV4 is a protein found in cells that plays a role in thermosensation and osmotic pressure. It contains a large intrinsic disorder region, IDA, which is composed of 150 amino acids. The IDA interacts with lipids and other proteins to control the activity of TRPV4. By studying this region, researchers have discovered that the IDA can act as a master regulator, controlling the activity of TRPV4 by competing with another protein called PIP2. Additionally, they have shown that the IDA structure is dynamic and changes depending on the presence or absence of lipids. This study provides insight into how the IDA affects the activity of TRPV4 and how it can be used to control its activity. This article was authored by Benedict Goretzky, Christoph Weigman, Brett A. McCrae, and others.