 The development of drug candidates with greater lipophilicity, high molecular weight, and poor water solubility has led to challenges in new drug development due to low bioavailability resulting from issues associated with poor solubility. Insoluble drug delivery technologies have been successfully adopted by pharmaceutical companies to formulate poorly water soluble drugs into successful drug products, improving efficacy, safety, and patient compliance. This review covers recent advances in insoluble drug delivery and business prospects. This article was authored by Sandeep Kalapu and Vijay Kumar Nikanti.