 In this study, we investigated the effect of zinc oxide nanoparticles, ZNPs, on kidney health in rats. We found that exposure to low doses of ZNPs led to an increase in blood levels of zinc, which could be harmful if not regulated properly. Additionally, we observed a decrease in antioxidant enzyme activity, indicating that ZNPs make us oxidative stress in the kidneys. Furthermore, we saw a rise in blood urea nitrogen, BUN, creatinine, CR, and uric acid levels, suggesting that ZNPs can lead to kidney damage. Finally, we observed histological changes and an increase in apoptosis in the kidneys of animals exposed to higher doses of ZNPs. Overall, our results suggest that ZNPs should be used with caution and further research is needed to determine their safety in humans. This article was authored by Liasedad Corsandi, Abbas Haidari Moghadam, and Zara Josie.